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博士|【博士奖学金】最新PhD招生和奖学金信息（108）

_原题为 【博士奖学金】最新PhD招生和奖学金信息（108）
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【博士|【博士奖学金】最新PhD招生和奖学金信息（108）】01
Embedding STEM in Learning and Teaching
标签:
Central Queensland University | Australia
截止日期：
Applications accepted all year round
详细信息
博士|【博士奖学金】最新PhD招生和奖学金信息（108）
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Profile Deion
This project proposes to use vehicle system dynamics modelling, longitudinal train dynamics modelling and parallel computing to further develop and leverage the applications of three dimensional long train system dynamics simulations. Applicants are expected to have basic understanding of railway systems, vehicle system dynamics and programming skills.
Funding Notes
Funding is also provided by CQUniversity to support research higher degree student project costs, and to support national and international conference presentations. This includes:
For masters by research candidates:
- up to $4000 in Candidate Support Funds
- up to $3000 for Candidate Travel Support
For doctoral candidates:
- up to $6000 in Candidate Support Funds
- up to $4500 for Conference Travel Support
02
Characterisation of cell death pathways upon activation of the endoplasmic reticulum stress sensor IRE1alpha
标签:
Durham University| The UK
截止日期：
Friday, December 20, 2019
详细信息
博士|【博士奖学金】最新PhD招生和奖学金信息（108）
文章图片

Project Deion
A competition-funded Durham Doctoral studentship to investigate cell death pathways activated by endoplasmic reticulum (ER) stress is available in the group of Dr. Martin Schr?der in the Department of Biosciences at Durham University, Durham, United Kingdom.
Mammalian cells that experience ER stress mount a protective response to this stress, called the unfolded protein response (UPR), but commit to apoptotic cell death if the stress situation cannot be resolved (1,2). How cells make this decision between life and death remains poorly understood. To gain further insight into this fundamental question, this project will investigate how one ER stress sensor, IRE1alpha, commits cells to apoptotic cell death.
IRE1alpha is a transmembrane protein of the ER with cytosolic protein kinase and endoribonuclease (RNase) domains (1). Its ER luminal domain senses ER stress and activates its protein kinase and RNase domains to generate the ER stress signal. The RNase domain is thought to produce a largely cytoprotective signal by processing the mRNA for the tranion factor XBP1, while its protein kinase domain has been implicated in activating apoptotic signalling. This project will make use of a unique version of IRE1alpha developed at Durham University that can be activated independent of inducing ER stress.
The successful candidate will characterise whether activation of this version of IRE1alpha commits mammalian cells to apoptosis, characterise the signalling pathway downstream of IRE1alpha that lead to apoptotic cell death, and characterise which enzymatic activities of IRE1alpha, its protein kinase or endoribonuclease domain, are involved in generating the apoptotic signal. To address these aims, the student will use a range of molecular, cellular, and biochemical techniques, such as the construction of IRE1alpha mutants, stable transfection of mammalian cells, PCR techniques to monitor the RNase activity of IRE1alpha, Western blots to monitor phosphorylation and expression of IRE1alpha and apoptotic proteins, and cell biological assays to measure apoptosis.


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