医脉通心内科频道|警惕!这些药物可能引起QT间期延长|临床“药”点( 二 )

医脉通心内科频道|警惕!这些药物可能引起QT间期延长|临床“药”点
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小结
心血管系统不良反应是常见的药物相关不良事件 , 考虑到个体差异和药物间相互作用的复杂性 , 常常难以预测 。 因此 , 对于存在心动过缓、束支阻滞、基线QT间期稍长、血钾异常、心血管病史等QTc间期延长风险因素的患者 , 使用上述药物时须接受持续心电监测 。参考文献1. Trinkley KE, Page RL 2nd, Lien H, Yamanouye K, Tisdale JE. QT interval prolongation and the risk of torsades de pointes: essentials for clinicians. Curr Med Res Opin. 2013 Dec; 29(12): 1719-26.2. Beach SR, Celano CM, Sugrue AM, Adams C, Ackerman MJ, Noseworthy PA, Huffman JC. QT Prolongation, Torsades de Pointes, and Psychotropic Medications: A 5-Year Update. Psychosomatics. 2018 Mar-Apr; 59(2): 105-122.3. Murphy CA, Dargie HJ. Drug-induced cardiovascular disorders. Drug Saf. 2007; 30(9): 783-804.4. Kennelly C, Esaian D. Drug-induced cardiovascular adverse events in the intensive care unit. Crit Care Nurs Q. 2013 Oct-Dec; 36(4): 323-34.5. Isbister GK, Brown AL, Gill A, Scott AJ, et al. QT interval prolongation in opioid agonist treatment: analysis of continuous 12-lead electrocardiogram recordings. Br J Clin Pharmacol. 2017 Oct; 83(10): 2274-2282.


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