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柳叶刀TheLancet|中枢胰岛素信号、糖尿病、认知功能障碍之间的相互关联( 三 )


由于肥胖和2型糖尿病对年轻人群的影响越来越大 ， 我们有必要了解其潜在病理生理学的长期变化 ， 以及这些变化与痴呆症患病风险和临床轨迹之间的关联 。 END
参考文献（上下滑动查看）
1.van Sloten TT Sedaghat S Carnethon MR Launer LJ Stehouwer CDA Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression. Lancet Diabetes Endocrinol. 2020; 8: 325-336
2.Kullmann S Kleinridders A Small DM et al.Central nervous pathways of insulin action in the control of metabolism and food intake in humans.Lancet Diabetes Endocrinol. 2020; 8: 525-534
3.Liu S Borgland SLInsulin actions in the mesolimbic dopamine system.Exp Neurol. 2019; 320113006
4.Ruud J Steculorum SM Brüning JCNeuronal control of peripheral insulin sensitivity and glucose metabolism.Nat Commun. 2017; 815259
5.Srikanth V Sinclair A Hill-Briggs H Moran C Biessels G-JType 2 diabetes and cognitive dysfunction—towards effective management of both comorbidities.Lancet Diabetes Endocrinol. 2020; 8: 535-545
6.Punthakee Z Miller ME Launer LJ et al.Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: post hoc epidemiologic analysis of the ACCORD trial.Diabetes Care. 2012; 35: 787-793
7.Erus G Battapady H Zhang T et al.Spatial patterns of structural brain changes in type 2 diabetic patients and their longitudinal progression with intensive control of blood glucose.
Diabetes Care. 2015; 38: 97-104
8.Lewandowicz A Skowronek P Maksymiuk-K?os A Pi?tkiewicz PThe giant geriatric syndromes are intensified by diabetic complications.Gerontol Geriatr Med. 2018; 4 (2333721418817396.)
9.Arnold SE Arvanitakis Z Macauley-Rambach SL et al.Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums.Nat Rev Neurol. 2018; 14: 168-181
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*中文翻译仅供参考 ， 一切内容以英文原文为准 。


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